1.LYSOSOMALSTORAGEDISEASES

溶酶体贮积病

1.1Sphingolipidoses神经鞘脂贮积病

1.1.1Globoidcellleukodystrophy类球状细胞脑白质营养不良

Fig.1Globoidcellleukodystrophyina3-month-oldCairnTerrier.(a)ThistransverseT2Wimageshowsgeneralizeddiffuseincreaseinsignalintensityofcerebralwhitematter(arrows)andhypointensityofthethalamus(asterisk).(b)ThistransverseT1Wimageshowsmildincreasedsignalintensityofthecorpuscallosum(arrow).(1.5TMRIsystem;imagescourtesyofDrs.WilfriedMaiandCharlesVite,UniversityofPennsylvania)

图1一例3月龄凯恩犬的类球状细胞脑白质营养不良。(a)横断面T2W图像显示脑白质信号强度(箭号)普遍弥漫性增强，丘脑呈低信号(星号)。(b)横断面T1W图像显示胼胝体(箭号)信号强度轻度增强。

Fig.2GM1gangliosidosisina3-month-olddog.TransverseT2W(a)andT2-FLAIR(b)imagesdemonstratingdiffuseT2hyperintensityinthesubcorticalwhitematterofthecerebrum(arrows).(1.5TMRIsystem;reproduced,withpermission,fromHasegawaD,YamatoO,NakamotoYetal.().SerialMRIfeaturesofcanineGM1gangliosidosis:apossibleimagingbiomarkerfordiagnosisandprogressionofthedisease.ScientificWorldJournal,ArticleID,